Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
尽管当下是一个全球性的经济环境，但仅有约20%的美国人会说第二门语言。Sixty Vocab的目标就是以其在线外语游戏改变这一现状。基于2000个单词相当于一门外语的六成精髓的假设，Sixty Vocab试图使学习必要词汇的过程变得有趣。这些在线游戏能教你在对话中最为常用的词汇，并辅以限制时间的规则——你在越短的时间内猜出单词，你就能越快地进入到下一个阶段。Sixty Vocab填补了你高中课程和昂贵外语学习项目之间的空白，为那些想要在早餐咖啡或通勤时间学习一门外语的人提供了一个独一无二的选择。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The Tsinghua-Insead EMBA programme, launched in 2007, entered the FT rankings with a bang in 2012, going straight into fourth place with its very first cohort. The programme has since been ranked second, third, and finally has achieved first place in the rankings this year.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Saving Cancer Patients in Africa
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
China's movie box office revenue grew 9 percent to $8.9 billion (RMB 60.98 billion) in 2018.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Trends and targets in antiviral phototherapy
A lack of capital and experience is the biggest obstacle for college entrepreneurs, the report suggested, stating that 40 percent of such young entrepreneurs rely on external capital such as loans from banks, investment organizations, schools and the government.
Scientists have long investigated stem cells' potential for growing hearts, and they reached a major milestone this year when they created heart tissue than can beat on its own.
Developer: Remedy Entertainment, Microsoft Studios
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
5. “Carol” (Todd Haynes)
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
?All the Bond actors have been tall. This isn't a coincidence. A man who is five foot six needs to earn $175,000 a year more a year to be as attractive as a man who is six feet tall. A lot of people commented on Daniel Craig's buff physique in Casino Royale. Once again the depiction clicks with the research: muscular men have more one night stands and you can tell how many women a guy has slept with by the size of his arms. That chiseled torso may mean he's a better lover.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Some of them still give high return to their shareholders. China Merchants Bank is generous; its dividend reached 30.16% of its net profits.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Issued by the Institute of Social Security Research, Ministry of Human Resources and Social Security, the report shows that the return rate of enterprise employees' pension insurance fund reached 3.1 percent, the highest in seven years.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Xinhua reported in 2015 that the MOE and five other central government departments were putting together a task force to ensure that football thrives in the country's schools.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Much joy to you in the up coming year. May the warmest wishes, happy thoughts and friendly greetings come at New Year and stay with you all the year through.让温馨的祝愿、幸福的思念和友好的祝福，在新年来到你身边，伴你左右。
Antiviral drug discovery: broad-spectrum drugs from nature
They also arrived 40 minutes late for the official welcome and were running late to an event in Vancouver, too.
这段深入11岁女孩心灵与情感的旅程可能是皮克斯迄今最疯狂的冒险。这是一部非常有趣的工作场合情景喜剧，艾米·波勒(Amy Poehler)、菲利丝·史密斯(Phyllis Smith)和敏迪·卡灵(Mindy Kaling)等人带来了精彩感人的演出，这是一则关于心理发展的精巧语言，也是对于悲伤在我们的生活中所扮演的角色的一种感人而诚恳的辩护。
New construction will provide luxury options for renters with deep pockets, mostly in the boroughs outside Manhattan. In Brooklyn, 6,527 new rental units are expected to hit the rental market next year, nearly twice the 3,802 units anticipated for Manhattan, according to Citi Habitats.
Influenza neuraminidase: A druggable target for natural products
当芬兰程序员Jerry Jalava 2008年遇到车祸，他面临双重悲剧。首先，他失去了他的手指，对于靠打字生存的人来说是个大问题。其次，他必须跟一个幽默感过剩的医疗小组打交道。了解了他的遭遇后，一位外科医生竟然提议Jalava应该出门去买个“USB手指驱动器”。
The “cool” factor isn’t the only issue. Security and privacy, particularly around the management of consumer data, remain a concern as the tech industry seeks to bring more of our body parts online. As The Economist notes, the glamour of developing sensors and algorithms for wearables is distracting everyone from glaring missing elements, “standards, interoperability, integration and data management” and “intellectual-property rights and regulatory compliance” among them. All this in an environment where paranoia remains over the National Security Administration’s activities.
However, you know when your cycles are over when the washer and dryer stop making noise. And you know when the weather is ugly by simply looking outside, or checking your weather app. Therefore, the product is basically just another way hackers can get into your home.
As impressive as those saving gains might look now, they could easily be swallowed as rising rates of illness place a greater burden on society.
Mila Kunis placed second on the list, followed by Kate Upton, pop star Rihanna and Emma Stone.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
It is the first time since 2001 that an athlete other than Mayweather Jnr or golfer Tiger Woods topped the earning league.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The below are 5 companies that stand out from the rest and are startups to watch in 2014.
在纽约市许多公寓楼的大门背后，充斥着居民们不协调的抱怨声。从我的“房地产答疑”(Ask Real Estate)专栏所收到的抱怨信中，我们可以一窥居民们是如何应对生活在拥挤、昂贵的住房中的种种不顺心的。比方说，有个合作公寓的股东被邻居家的老鼠窝吓坏了；有一对父母被禁止将婴儿车推进楼内的电梯；有个租户厨房里的橱柜从墙壁上掉了下来。
Faber laughs at Bernanke's remark that the economy would be strong enough later this year so he could take his foot off the gas, that is begin 'tapering, or scaling back it's stimulative quantitative easing (QE) program later this year.' Yes, laughed.
This year's new college grads entering the workforce are being offered an average monthly salary of 4,014 yuan ($582), and about one-third of them chose to work in first-tier cities, according to survey results released by zhaopin.com, a Chinese online recruitment service provider.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Yet disparities were clear among sectors and companies.
Bond King Bill Gross admits, 'QE must end.' Trillions of cheap money 'has distorted incentives and inflated asset prices to artificial levels.' But now Gross says 'the Fed plan may be too hasty.'
With Capital Economics estimating that global economic growth will edge up to 2.8 per cent this year, from 2.5 per cent in 2016, “the exports of the emerging world’s net commodity exporters should rise by about 20 per cent year-on-year in dollar terms,” he argues.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
The Olympic games are a time when the countries of the world should put aside their differences to engage in sport. Whether that actually happens, however, is debatable. While the athletes are surely capable of focusing on the competition, it can be hard for long-standing disagreements to be forgotten -- even temporarily -- by their home countries.
Its selection of Mr Trump neither accords with the votes cast in the election nor reflects judgment of the candidate’s merits, as desired by Alexander Hamilton.
The questions New Yorkers ask the column are dictated not only by their individual circumstances but also by the larger issues of the day, like rising housing costs, gentrification and shoddy construction. In the end, 2014 was a year of things going up — home prices, rents and, above all, buildings, with 16,700 units approved for construction through October, according to the Real Estate Board of New York.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The city offers excitement beyond your expectations, with grand churches, a richly varied number of museums, a growing modern-art scene and streets that come alive with summer festivals.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Additional reporting by Ma Nan
Best chances: Best film and best director. Surprisingly, Nolan has never received a directing nomination from the Academy.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Meanwhile, in recent months mainland investors have been rapidly owning equity trading accounts and putting money into the stock market. The Shanghai Composite has become the region's best performing index, rising nearly 45 per cent year to date.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
I know a lot more about you when you walk in the door than you realize. I'll search for you on the web and often use my own personal network to do a pre-interview reference check.
Piano and ballet performance “On My Fingertips And Toes” (Lang Lang and Hou Honglan)
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Ultimately I expect these new leaders to start selecting from a broader pool of candidates and appoint direct reports from more varied backgrounds, defying those who use current imbalances to extrapolate gloomily that leadership parity between men and women is still decades off.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
With the right tools in place, you’ll find yourself more productive and efficient.
But that kind of emotional identification gets lost on the runway, and the retail floor. And then we are left with what?
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Apple tops the list of World's 500 Most Influential Brands for 2016, compiled by New York-based World Brand Lab and released last Monday.
Goldman Sachs will pay out big bonuses, be publicly vilified for a month and then go quietly back to printing profits.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Hope you enjoy the happiness of New Year and all the trimmings.祝你享尽新年佳节的快乐和新年的礼品。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
我们从中精选了110部新剧和回归剧，又进一步缩减到下面的20部剧（内中没有包括HBO台的《真探》[True Detective]，因为它被移到今年晚些时候，亦不包括《权力的游戏》[Game of Thrones]、《副总统》[Veep]和《硅谷》[Silicon Valley]，其中《硅谷》将在四月播出第一集，具体日期未宣布）。从《绝命毒师》(Breaking Bad)的衍生剧到《小镇疑云》(Broadchurch)的回归，再到《火线警探》的最终季，冬天真是电视剧迷的好时光。
However the prolonged period of contraction fits with the overall pattern of the slowing Chinese economy.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
6.I’m 29. – Because 29 is like 20 years younger than 30.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
While Jaws's story is extremely unrealistic, it was based on a real series of deaths attributed to a single shark in 1916. In what has been dubbed the "most unique set of shark attacks that ever have occurred," the Jersey Shore saw four people die from shark bites over the course of two weeks. The offending shark was reportedly caught with body parts still in its digestive tract, although leading scientists still aren't sure what drove it to attack so many people.
As the cameras cut away to the cast and crew of "La La Land" hugging, Beatty could be heard saying something such as, "It says Emma Stone," with Dunaway replying, "What?" As the La La Land cast were walking on stage to accept the accolade, a stagehand standing in the wings could be heard saying "Oh ... Oh my god, he got the wrong envelope".
虽然汉德曾在英国石油公司（British Petroleum）担任过多年全球品牌、营销与创新高级副总裁，但她现在却在从事更加环保的事业。Project Frog的使命是希望通过易于建造的空间（通常几天或者几个月便可完成），彻底改造建筑行业。相比教育与医疗等行业的传统建筑，Project Frog的建筑可以节省约50%的能源。汉德的计划似乎已经奏效：公司今年的收入预计将增加一倍以上。
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
But closing the deal on RCEP less than a year after Donald Trump pulled the US out of the TPP would be a big win for Beijing.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
I'm pleased to see manufacturing jobs returning to the U.S., but I don't expect the manufacturing industry to have the galvanic effect on the economy that many hope for. Why? Because automation will sharply erode the number of jobs any factory requires. The disappearance of blue-collar and entry-level jobs is already a problem, and that problem will grow.
6.Jack Shephard Almost Died in the First Episode
狄娜莎(Tinashe)与德文戴·西尼斯(Devonté Hynes)，《打赌》(Bet)， RCA
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
CANCER: THE EMPEROR OF ALL MALADIES (PBS, March 30) Barak Goodman (“Scottsboro: An American Tragedy,” “My Lai”) is the director and Ken Burns is an executive producer of this six-hour series based on the Pulitzer Prize-winning book “The Emperor of All Maladies: A Biography of Cancer” by Dr. Siddhartha Mukherjee.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
In the 1990s, Roth applied it to the market for allocating US student doctors to hospitals. He developed a new algorithm that was adopted by the National Resident Matching Program, which helps match resident doctors with the right hospitals.
13. “Girlhood” (Céline Sciamma)
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
It was apparent not just in obvious brand extensions, like Banana Republic’s “Mad Men” collection (designed in collaboration with the show’s costume supremo, Janie Bryant), but in more pervasive, unspoken ways: in silhouette and print; in hemline and seam. And in the clear belief, visible on catwalks everywhere, that the 1960s were the answer to every moment of pallid inspiration, or aesthetic doubt.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Shares in Hyundai and AmorePacific slid on Friday, down 4.4 per cent and 12.5 per cent respectively in late afternoon trading in Seoul.
A study cited in an article from Harvard University suggests your diet could have a significant impact on your memory as you age. Scientists at Brigham and Women's Hospital published a study within the "Annals of Neurology" that suggested women who ate high levels of saturated fat in foods like red meat and butter didn't perform as well on memory tests than women who regularly consumed less saturated fat. Researchers haven't yet discovered the connection between saturated fat and memory, but they hypothesize it could have something to do with a person's genes. Scientists and doctors have long recommended that patients work to control their cholesterol levels as they age to protect the memory during the aging process.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Beauty and Evolution
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
It was the spring of hope, it was the winter of despair…
There were also shows that didn’t live up to early expectations but still had traction, most notably “The Affair,” on Showtime, which began as a Hamptons film noir and instead turned into a French art film. The crime may not be commensurate with the series’s punishingly slow pace and “Rashomon"-like storytelling, but the series picked up momentum — and suspense — in the final episodes.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The developer behind Kinect Disneyland Adventures and Elite: Dangerous is taking the theme park business to the extreme in ScreamRide. The game lets players build outrageous roller coasters, thrill rides and attractions from the ground up and then take them for a test run. The game offers three ways to play: Engineers can construct elaborate rides that test the boundaries of physics and g-forces; Scream Riders get on these rides and experience the thrills and spills first-hand – sometimes resulting in untimely deaths; and Demolition Experts can use any means necessary to tear down an entire amusement park. With classic PC games like Roller Coaster Tycoon now playable on smartphones, this next generation of thrill-ride creator is a welcome interactive experience. It’s always fun to build, ride and destroy roller coasters – and ScreamRide offers plenty of ways to share the thrills with your friends.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
那些原本希望今年凭借战术策略获得些利益的财务顾问和资产配置人员，也在反复无常的市场中栽了跟头。全美前三位的战术策略产品中，有两款产品几乎因为高达两位数的亏损而崩盘，还有一款产品则因为向公众误报自身历史回报率而受到美国证交会调查。另一家战术产品巨头嘉信理财旗下90亿美元的Windhaven Diversified Growth产品，2014年的回报率几乎为零。战术策略原来不过如此。
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Yao Zhenhua, the chairman of Baoneng Group and the biggest riser since 2015, saw his wealth shoot up 820 percent to $17.2 billion, elevating him to fourth in the overall list.
Length-scale dependence of protein hydration-shell density
This year's best midseason trade action happened early:
When I am creating a light novel, Iam creating it mostly alone. When I am working on anime there is a director andthe staff with a point of view on my works. There usually are several revisionsregarding the storyboard. What is interesting is what will come back. It's avery interesting part of the work.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Britain saw a 66 percent increase in its foreign-born population between 2004 and 2014. Voters who chose “leave” in the recent referendum overwhelmingly cited immigration as their main concern.
About this collection
Regulators clamped down on outbound deals following an unprecedented flood of offshore acquisitions in 2016 that drained China’s foreign exchange reserves. In August this year, China’s cabinet formalised a new framework that encourages deals that fit Beijing’s strategic priorities and discourages deals in entertainment, sports and luxury real estate