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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

【中文译文】
尽管当下是一个全球性的经济环境,但仅有约20%的美国人会说第二门语言。Sixty Vocab的目标就是以其在线外语游戏改变这一现状。基于2000个单词相当于一门外语的六成精髓的假设,Sixty Vocab试图使学习必要词汇的过程变得有趣。这些在线游戏能教你在对话中最为常用的词汇,并辅以限制时间的规则——你在越短的时间内猜出单词,你就能越快地进入到下一个阶段。Sixty Vocab填补了你高中课程和昂贵外语学习项目之间的空白,为那些想要在早餐咖啡或通勤时间学习一门外语的人提供了一个独一无二的选择。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

The Tsinghua-Insead EMBA programme, launched in 2007, entered the FT rankings with a bang in 2012, going straight into fourth place with its very first cohort. The programme has since been ranked second, third, and finally has achieved first place in the rankings this year.
● “一男子持枪自拍时不小心把自己JJ射了”

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 工信部今日发放5G商用牌照
Open Access Perspective

Soft matter science and the COVID-19 pandemic

Saving Cancer Patients in Africa

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

China's movie box office revenue grew 9 percent to $8.9 billion (RMB 60.98 billion) in 2018.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 2月 返乡置业“春节来袭”
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

后来此护符被拿去实验室检测,知道上个月,Spielman一家才接到电话,被告知检测结果。
公司:儿童用品公司BooginHead
和过去几年相比,2013年信心受到动摇的时候少了,但市场依然很容易受到影响。OppenheimerFunds的首席经济学家韦布曼(Jerry Webman)表示,虽然2013年的信心要强于以往,但全球各地也不都是这样。
intended

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

A lack of capital and experience is the biggest obstacle for college entrepreneurs, the report suggested, stating that 40 percent of such young entrepreneurs rely on external capital such as loans from banks, investment organizations, schools and the government.
Scientists have long investigated stem cells' potential for growing hearts, and they reached a major milestone this year when they created heart tissue than can beat on its own.
通过药物注射传播艾滋病病毒的情况已得到有效控制。2017年,经注射吸毒感染者的人数相比2012年下降44.5%。
Developer: Remedy Entertainment, Microsoft Studios

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 石材行业洗牌 人造石降成本
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

5. “Carol” (Todd Haynes)

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 湖南整治不动产登记窗口作风问题
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

骑行背带

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

从2004年起,过去120年里的现代或当代艺术家们创作的10件作品在拍卖会上共卖出1亿多美元。而更早期绘画大师的作品价格则是稳中有跌。最近几周,这一趋势非常明显,伦敦的拍卖公司努力为自己的最新一批18世纪前绘画大师作品寻找买家。与近些年的情况一样,其中几乎没有名作。
例如,美国和亚洲向投资者推介产品的方式存在明显区别。在亚洲,很大比例的基金(一些人估计为90%)是以佣金为基础。这对ETF不利,因为它们在股票交易所公开交易,在结构上不便向可能推荐它们的银行、券商或理财顾问支付佣金,这与该地区的共同基金行业不同。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

2012年伦敦奥运会室内自行车比赛场馆2012年伦敦奥运会共设26个大项,总计300个小项比赛cupIHumCfz。比赛大项和小项均少于2008年北京奥运会sgK8=M,J)Qa&g9sAp!,。
?All the Bond actors have been tall. This isn't a coincidence. A man who is five foot six needs to earn $175,000 a year more a year to be as attractive as a man who is six feet tall. A lot of people commented on Daniel Craig's buff physique in Casino Royale. Once again the depiction clicks with the research: muscular men have more one night stands and you can tell how many women a guy has slept with by the size of his arms. That chiseled torso may mean he's a better lover.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

据哈佛大学校报报道,至少10名学生因在脸书私聊小组中发布“猥琐表情”而失去哈佛大学的入学资格。
在360000个网红账号中,女性达到74%。而87.8%的网红年龄都在17-33岁之间,89%的网红接受过高等教育。

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 新世纪光电完成5亿元再融资案
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

2013年排名:14
本默切重振公司士气的艰苦努力将取得回报。美国“薪酬沙皇”将对他网开一面。而且各个市场的持续回暖将令公司有机会偿还一大笔美国纳税人的救助资金。
在经济大幅放缓和复苏不顺的过程中,美联储的计划几乎都没有按照原先设定的那样去实施,美联储官员们现在也公开承认了这一事实。美联储主席贝南克(Ben Bernanke)上个月在其最后一次新闻发布会上表示,美联储对于增长步伐感到失望,同时也没有完全弄明白其中的原因。
Some of them still give high return to their shareholders. China Merchants Bank is generous; its dividend reached 30.16% of its net profits.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

n. 利益,津贴,保险金,义卖,义演

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Issued by the Institute of Social Security Research, Ministry of Human Resources and Social Security, the report shows that the return rate of enterprise employees' pension insurance fund reached 3.1 percent, the highest in seven years.
11 August

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Xinhua reported in 2015 that the MOE and five other central government departments were putting together a task force to ensure that football thrives in the country's schools.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Much joy to you in the up coming year. May the warmest wishes, happy thoughts and friendly greetings come at New Year and stay with you all the year through.让温馨的祝愿、幸福的思念和友好的祝福,在新年来到你身边,伴你左右。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

《无为大师》
They also arrived 40 minutes late for the official welcome and were running late to an event in Vancouver, too.
这段深入11岁女孩心灵与情感的旅程可能是皮克斯迄今最疯狂的冒险。这是一部非常有趣的工作场合情景喜剧,艾米·波勒(Amy Poehler)、菲利丝·史密斯(Phyllis Smith)和敏迪·卡灵(Mindy Kaling)等人带来了精彩感人的演出,这是一则关于心理发展的精巧语言,也是对于悲伤在我们的生活中所扮演的角色的一种感人而诚恳的辩护。
New construction will provide luxury options for renters with deep pockets, mostly in the boroughs outside Manhattan. In Brooklyn, 6,527 new rental units are expected to hit the rental market next year, nearly twice the 3,802 units anticipated for Manhattan, according to Citi Habitats.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

当芬兰程序员Jerry Jalava 2008年遇到车祸,他面临双重悲剧。首先,他失去了他的手指,对于靠打字生存的人来说是个大问题。其次,他必须跟一个幽默感过剩的医疗小组打交道。了解了他的遭遇后,一位外科医生竟然提议Jalava应该出门去买个“USB手指驱动器”。
The “cool” factor isn’t the only issue. Security and privacy, particularly around the management of consumer data, remain a concern as the tech industry seeks to bring more of our body parts online. As The Economist notes, the glamour of developing sensors and algorithms for wearables is distracting everyone from glaring missing elements, “standards, interoperability, integration and data management” and “intellectual-property rights and regulatory compliance” among them. All this in an environment where paranoia remains over the National Security Administration’s activities.
However, you know when your cycles are over when the washer and dryer stop making noise. And you know when the weather is ugly by simply looking outside, or checking your weather app. Therefore, the product is basically just another way hackers can get into your home.
As impressive as those saving gains might look now, they could easily be swallowed as rising rates of illness place a greater burden on society.
Mila Kunis placed second on the list, followed by Kate Upton, pop star Rihanna and Emma Stone.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

尽管中国的私人财富大幅增长,但中国的亿万富豪仍未跻身全球顶级富豪行列。胡润估计,中国首富、万达集团(Wanda Group)掌门人王健林在全球富豪中排名第26位。
It is the first time since 2001 that an athlete other than Mayweather Jnr or golfer Tiger Woods topped the earning league.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

上榜理由:被低估的欧洲瑰宝

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

今年,该学校首次跻身前20强。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

The below are 5 companies that stand out from the rest and are startups to watch in 2014.
在纽约市许多公寓楼的大门背后,充斥着居民们不协调的抱怨声。从我的“房地产答疑”(Ask Real Estate)专栏所收到的抱怨信中,我们可以一窥居民们是如何应对生活在拥挤、昂贵的住房中的种种不顺心的。比方说,有个合作公寓的股东被邻居家的老鼠窝吓坏了;有一对父母被禁止将婴儿车推进楼内的电梯;有个租户厨房里的橱柜从墙壁上掉了下来。
Faber laughs at Bernanke's remark that the economy would be strong enough later this year so he could take his foot off the gas, that is begin 'tapering, or scaling back it's stimulative quantitative easing (QE) program later this year.' Yes, laughed.
This year's new college grads entering the workforce are being offered an average monthly salary of 4,014 yuan ($582), and about one-third of them chose to work in first-tier cities, according to survey results released by zhaopin.com, a Chinese online recruitment service provider.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
From the themed collection: 低碳来袭 家居业再不追赶就OUT了
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Yet disparities were clear among sectors and companies.
Bond King Bill Gross admits, 'QE must end.' Trillions of cheap money 'has distorted incentives and inflated asset prices to artificial levels.' But now Gross says 'the Fed plan may be too hasty.'
With Capital Economics estimating that global economic growth will edge up to 2.8 per cent this year, from 2.5 per cent in 2016, “the exports of the emerging world’s net commodity exporters should rise by about 20 per cent year-on-year in dollar terms,” he argues.
无论是左翼还是右翼,他们都标榜自己是反精英的大众代表和不合适的局外人,并作为魅力领导人与追随者密切联系,他们往往通过弥天大谎来操纵这种联系,用以谋求自己的进步;他们威胁既有的行为准则和约束性制度,把这些准则和制度描述为他们所代表的民意的敌人。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

n. 利益,津贴,保险金,义卖,义演
9)做得不错:毫无疑问,这有点陈词滥调的味道。有时,仅说一句“谢谢”还不够。人们想知道他们的工作完成得是否出色,也想知道为什么他们工作干的出色。毕竟,他们为项目流了太多的汗水,倾注了太多的心血。他们需要知道自己的工作很特别且是有意义的。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 泉州建材联盟合奏产业强音
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

温莎王朝的非官方座右铭“永不抱怨,永不解释”到底可信不可信?
The Olympic games are a time when the countries of the world should put aside their differences to engage in sport. Whether that actually happens, however, is debatable. While the athletes are surely capable of focusing on the competition, it can be hard for long-standing disagreements to be forgotten -- even temporarily -- by their home countries.
Its selection of Mr Trump neither accords with the votes cast in the election nor reflects judgment of the candidate’s merits, as desired by Alexander Hamilton.
亚洲的商界女性在崛起:整个亚洲地区在榜单上的表现都非常抢眼,从中国和新加坡到新西兰和泰国,都能找到女强人的身影。亚洲的女性企业家群体正在崛起,例如张欣(排名第50)、孙亚芳(排名第77)和周凯旋(排名第80)。在政界,亚洲女性也在施展自己的抱负,例如新上榜的韩国总统朴槿惠(排名第11),缅甸反对派领袖、国会议员昂山素季(排名第29),澳大利亚总理茱莉亚·杰拉德(排名第28),以及泰国总理英拉·西那瓦(排名第31)。
The questions New Yorkers ask the column are dictated not only by their individual circumstances but also by the larger issues of the day, like rising housing costs, gentrification and shoddy construction. In the end, 2014 was a year of things going up — home prices, rents and, above all, buildings, with 16,700 units approved for construction through October, according to the Real Estate Board of New York.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

还是说回TextPride吧。雷和欧布莱恩发现,用户很喜欢各种品牌授权的表情符号,他们相信广告主肯定希望非常便捷地通过一家供应商来进入多种短信应用。但他们也明白,这充其量只能占到这项业务的一半份额。对运动队这类大名鼎鼎的品牌来说,用户是愿意为这些贴纸埋单的。但那些不知名的品牌就需要自己掏钱来挤进这个圈子了。
谎言8:我写了5页的简历,那是因为我足够好。说谎原因:我就是个不折不扣的话唠!
The city offers excitement beyond your expectations, with grand churches, a richly varied number of museums, a growing modern-art scene and streets that come alive with summer festivals.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Additional reporting by Ma Nan
Best chances: Best film and best director. Surprisingly, Nolan has never received a directing nomination from the Academy.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 房地产调控总基调没有变
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

祝你享尽新年佳节的快乐和新年的礼品。
Everything Else
Meanwhile, in recent months mainland investors have been rapidly owning equity trading accounts and putting money into the stock market. The Shanghai Composite has become the region's best performing index, rising nearly 45 per cent year to date.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

I know a lot more about you when you walk in the door than you realize. I'll search for you on the web and often use my own personal network to do a pre-interview reference check.
Piano and ballet performance “On My Fingertips And Toes” (Lang Lang and Hou Honglan)
但关于是否会诞生另一个火爆产品,来打破关于后乔布斯时代苹果前途的质疑,库克许久以前就学会了耐心和相信自己的直觉,正如他在1998年加入正处在困境中的苹果时对质疑者置之不理一样。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

受到国家经济全面紧缩的影响,正面临弹劾的巴西总统迪尔玛?罗塞夫在去年十月时年收入下滑至10.34万美元,与之前相比下降10%。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

伞上的链子可以系在狗狗的项圈或背带上。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Ultimately I expect these new leaders to start selecting from a broader pool of candidates and appoint direct reports from more varied backgrounds, defying those who use current imbalances to extrapolate gloomily that leadership parity between men and women is still decades off.
谁都有不如意的时候,但是佳士得拍卖会上令人失望的情景已经不是第一次出现。今年7月的18世纪前绘画大师作品拍卖会仅拍得1900万英镑,而当时的最低预估价是3150万英镑。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

With the right tools in place, you’ll find yourself more productive and efficient.
但科学研究和技术服务领域企业的高管薪酬却下降了4.2%。
在主持过去年的奥斯卡颁奖典礼、之前的格莱美奖及艾美奖之后,她无疑是这个角色的最佳选择。
But that kind of emotional identification gets lost on the runway, and the retail floor. And then we are left with what?

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

facile(adj 易做到的;不花力气的;性格温和的)face,le乐:想让脸乐还不容易吗?Fac=face,ilit,ate吃:用脸吃饭还不容易吗?
一位毕业生表示:“伦敦商学院拓宽了我的专业视野,开启了国际职业机遇。”他补充称:“在毕业后的3年里,我在美国、加拿大和香港工作过,辗转于公司银行业务、债务资本市场等多个领域。”

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Apple tops the list of World's 500 Most Influential Brands for 2016, compiled by New York-based World Brand Lab and released last Monday.
Goldman Sachs will pay out big bonuses, be publicly vilified for a month and then go quietly back to printing profits.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Hope you enjoy the happiness of New Year and all the trimmings.祝你享尽新年佳节的快乐和新年的礼品。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

相比之下,小型货车销量却开始走下坡路,其成交量仅为7.13万台,同比跌幅31%。
我们从中精选了110部新剧和回归剧,又进一步缩减到下面的20部剧(内中没有包括HBO台的《真探》[True Detective],因为它被移到今年晚些时候,亦不包括《权力的游戏》[Game of Thrones]、《副总统》[Veep]和《硅谷》[Silicon Valley],其中《硅谷》将在四月播出第一集,具体日期未宣布)。从《绝命毒师》(Breaking Bad)的衍生剧到《小镇疑云》(Broadchurch)的回归,再到《火线警探》的最终季,冬天真是电视剧迷的好时光。
However the prolonged period of contraction fits with the overall pattern of the slowing Chinese economy.
这一奖项于3月14日在阿姆斯特丹公布,是基于对全球上百万名旅客的调查而选出的。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

卡塔尔大学被选为最国际化的学校,这也标志着来自中东的大学第一次高居榜首。
6.I’m 29. – Because 29 is like 20 years younger than 30.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

While Jaws's story is extremely unrealistic, it was based on a real series of deaths attributed to a single shark in 1916. In what has been dubbed the "most unique set of shark attacks that ever have occurred," the Jersey Shore saw four people die from shark bites over the course of two weeks. The offending shark was reportedly caught with body parts still in its digestive tract, although leading scientists still aren't sure what drove it to attack so many people.
As the cameras cut away to the cast and crew of "La La Land" hugging, Beatty could be heard saying something such as, "It says Emma Stone," with Dunaway replying, "What?" As the La La Land cast were walking on stage to accept the accolade, a stagehand standing in the wings could be heard saying "Oh ... Oh my god, he got the wrong envelope".
虽然汉德曾在英国石油公司(British Petroleum)担任过多年全球品牌、营销与创新高级副总裁,但她现在却在从事更加环保的事业。Project Frog的使命是希望通过易于建造的空间(通常几天或者几个月便可完成),彻底改造建筑行业。相比教育与医疗等行业的传统建筑,Project Frog的建筑可以节省约50%的能源。汉德的计划似乎已经奏效:公司今年的收入预计将增加一倍以上。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

5. 持续行动
自从在2009年从榜单的第一位落到第五位之后,小甜甜布兰妮的排名继续下滑,随着嘎嘎小姐和贾斯汀 比伯这些新星的走红,布兰妮在2010年仅名列第十位。
这难道不是我们所有人都想要的吗?唐·德雷珀(Don Draper)应该会理解的。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

But closing the deal on RCEP less than a year after Donald Trump pulled the US out of the TPP would be a big win for Beijing.
难怪现代和当代艺术品拍卖市场的主要玩家佳士得拍卖行把自己的早期绘画大师作品重新宣传为“古典艺术品”。它将于明年4月(原先的计划是明年1月)在洛克菲勒中心(Rockefeller Center)举办早期绘画大师作品及其他历史作品拍卖会,其中包括20世纪作品专题拍卖会。周五(12月18日),佳士得称,它的“古典艺术品”拍卖计划将于明年7月在伦敦公布。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 三四线城市个贷增长明显
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 2025聚氨酯涂料市场将达55亿美元
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

calendar
在主持过去年的奥斯卡颁奖典礼、之前的格莱美奖及艾美奖之后,她无疑是这个角色的最佳选择。
n. 怪

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

用这个背带背孩子更加方便舒适。
节目24 土耳其风情舞蹈《火》,土耳其火舞舞蹈团

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

I'm pleased to see manufacturing jobs returning to the U.S., but I don't expect the manufacturing industry to have the galvanic effect on the economy that many hope for. Why? Because automation will sharply erode the number of jobs any factory requires. The disappearance of blue-collar and entry-level jobs is already a problem, and that problem will grow.
6.Jack Shephard Almost Died in the First Episode
狄娜莎(Tinashe)与德文戴·西尼斯(Devonté Hynes),《打赌》(Bet), RCA

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

CANCER: THE EMPEROR OF ALL MALADIES (PBS, March 30) Barak Goodman (“Scottsboro: An American Tragedy,” “My Lai”) is the director and Ken Burns is an executive producer of this six-hour series based on the Pulitzer Prize-winning book “The Emperor of All Maladies: A Biography of Cancer” by Dr. Siddhartha Mukherjee.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

谷歌2017全球搜索排名前十
支持:该片在威尼斯电影节首映后,获得观众喝彩。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

In the 1990s, Roth applied it to the market for allocating US student doctors to hospitals. He developed a new algorithm that was adopted by the National Resident Matching Program, which helps match resident doctors with the right hospitals.
13. “Girlhood” (Céline Sciamma)

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 津沪闽粤禁止新建溶剂型涂料项目
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

总体来看,36%的人相信末日论,而63%的人相信是气候变化的结果。
It was apparent not just in obvious brand extensions, like Banana Republic’s “Mad Men” collection (designed in collaboration with the show’s costume supremo, Janie Bryant), but in more pervasive, unspoken ways: in silhouette and print; in hemline and seam. And in the clear belief, visible on catwalks everywhere, that the 1960s were the answer to every moment of pallid inspiration, or aesthetic doubt.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

这项技术曾经运用于武器,但是运用在仿生腿上会更复杂。误读信号可能导致安装者跳下桥或站在开动的车辆前,依靠思想控制的仿生腿需要比武器更为复杂的程序。正如研究者指出的那样:如果你使用仿生胳膊,而胳膊动作做错了,可能只是手肘偏移预订位置。而如果仿生腿动作做错了,那可能就是生命安全问题了。
新兴市场GDP增速会超过5%吗?

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

而如果国王队签位掉出前10的话公牛队又会得到他们的签,所以在不妨碍球队重建的情况下,国王队不仅仅是不能进入季后赛,最好还是在倒数前十的队列中。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 2014建材行业格局分析
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Shares in Hyundai and AmorePacific slid on Friday, down 4.4 per cent and 12.5 per cent respectively in late afternoon trading in Seoul.
A study cited in an article from Harvard University suggests your diet could have a significant impact on your memory as you age. Scientists at Brigham and Women's Hospital published a study within the "Annals of Neurology" that suggested women who ate high levels of saturated fat in foods like red meat and butter didn't perform as well on memory tests than women who regularly consumed less saturated fat. Researchers haven't yet discovered the connection between saturated fat and memory, but they hypothesize it could have something to do with a person's genes. Scientists and doctors have long recommended that patients work to control their cholesterol levels as they age to protect the memory during the aging process.
衷心祝福来年快乐、幸运!
adj. 勤奋的,用功的

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Beauty and Evolution

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

It was the spring of hope, it was the winter of despair…
Time Management
There were also shows that didn’t live up to early expectations but still had traction, most notably “The Affair,” on Showtime, which began as a Hamptons film noir and instead turned into a French art film. The crime may not be commensurate with the series’s punishingly slow pace and “Rashomon"-like storytelling, but the series picked up momentum — and suspense — in the final episodes.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

The developer behind Kinect Disneyland Adventures and Elite: Dangerous is taking the theme park business to the extreme in ScreamRide. The game lets players build outrageous roller coasters, thrill rides and attractions from the ground up and then take them for a test run. The game offers three ways to play: Engineers can construct elaborate rides that test the boundaries of physics and g-forces; Scream Riders get on these rides and experience the thrills and spills first-hand – sometimes resulting in untimely deaths; and Demolition Experts can use any means necessary to tear down an entire amusement park. With classic PC games like Roller Coaster Tycoon now playable on smartphones, this next generation of thrill-ride creator is a welcome interactive experience. It’s always fun to build, ride and destroy roller coasters – and ScreamRide offers plenty of ways to share the thrills with your friends.
中国富人2014年在海外购买了至少7块小岛。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 全屋定制成为卫浴行业新模式
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

那些原本希望今年凭借战术策略获得些利益的财务顾问和资产配置人员,也在反复无常的市场中栽了跟头。全美前三位的战术策略产品中,有两款产品几乎因为高达两位数的亏损而崩盘,还有一款产品则因为向公众误报自身历史回报率而受到美国证交会调查。另一家战术产品巨头嘉信理财旗下90亿美元的Windhaven Diversified Growth产品,2014年的回报率几乎为零。战术策略原来不过如此。
a不,非,mnes记忆-不记仇-赦免

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

交通运输部新闻发言人徐成光通报称,未发现更多生命迹象,搜寻到生还者的希望"非常渺茫"。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

n. 文件,公文,文档
你如何知道你需要喝水了?这有一系列的诱因:嘴唇发干、头晕、头痛、尿量低和口渴。然而,这种智能瓶能在你的身体意识到缺水前就提醒你。
Yao Zhenhua, the chairman of Baoneng Group and the biggest riser since 2015, saw his wealth shoot up 820 percent to $17.2 billion, elevating him to fourth in the overall list.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

This year's best midseason trade action happened early:
美国两个城市的生活成本都有了显著增长,洛杉矶上升了19个名次进入前十。
阿德瑞娜利玛穿上了红色,亚历山大安布罗休惊艳四座,你能想到她刚生完孩子么?
When I am creating a light novel, Iam creating it mostly alone. When I am working on anime there is a director andthe staff with a point of view on my works. There usually are several revisionsregarding the storyboard. What is interesting is what will come back. It's avery interesting part of the work.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

此外,这也是北京大学连续第二年在亚洲大学排行榜上排名第二位。
在证监会分类的18个行业中,金融业高管以2736万元的年薪排名第一,地产业高管以1118万元的年薪位居次席。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

上榜的12所美国学院平均而言是性别比例最为平衡的,女性学员比例为48%。
LEAST LADYLIKE
Britain saw a 66 percent increase in its foreign-born population between 2004 and 2014. Voters who chose “leave” in the recent referendum overwhelmingly cited immigration as their main concern.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 家居建材产品藏多种安全隐患
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Regulators clamped down on outbound deals following an unprecedented flood of offshore acquisitions in 2016 that drained China’s foreign exchange reserves. In August this year, China’s cabinet formalised a new framework that encourages deals that fit Beijing’s strategic priorities and discourages deals in entertainment, sports and luxury real estate
他们必须发自内心地明白,通过操纵选举、打击异见或者骚扰反对派让临时权力永久化是不合法的。

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